human
Complete the below
def _ml(seq1, seq2, cmethod, codon_table):

    ''''ML method main function (PRIVATE).'
    '''

Give me a the Python program you requested?
assistant
#Here is the Python program you requested.
    from collections import Counter
    from scipy.optimize import minimize
    codon_cnt = Counter()
    pi = _get_pi(seq1, seq2, cmethod, codon_table=codon_table)
    for (i, j) in zip(seq1, seq2):
        if ('---' not in (i, j)):
            codon_cnt[(i, j)] += 1
    codon_lst = [i for i in (list(codon_table.forward_table.keys()) + codon_table.stop_codons) if ('U' not in i)]
    def func(params, pi=pi, codon_cnt=codon_cnt, codon_lst=codon_lst, codon_table=codon_table):
        'Temporary    function,    params    =    [t,    k,    w].'
        return (- _likelihood_func(params[0], params[1], params[2], pi, codon_cnt, codon_lst=codon_lst, codon_table=codon_table))
    opt_res = minimize(func, [1, 0.1, 2], method='L-BFGS-B', bounds=((1e-10, 20), (1e-10, 20), (1e-10, 10)), tol=1e-05)
    (t, k, w) = opt_res.x
    Q = _get_Q(pi, k, w, codon_lst, codon_table)
    Sd = Nd = 0
    for (i, c1) in enumerate(codon_lst):
        for (j, c2) in enumerate(codon_lst):
            if (i != j):
                try:
                    if (codon_table.forward_table[c1] == codon_table.forward_table[c2]):
                        Sd += (pi[c1] * Q[(i, j)])
                    else:
                        Nd += (pi[c1] * Q[(i, j)])
                except KeyError:
                    pass
    Sd *= t
    Nd *= t
    opt_res = minimize(func, [1, 0.1, 2], method='L-BFGS-B', bounds=((1e-10, 20), (1e-10, 20), (1, 1)), tol=1e-05)
    (t, k, w) = opt_res.x
    Q = _get_Q(pi, k, w, codon_lst, codon_table)
    rhoS = rhoN = 0
    for (i, c1) in enumerate(codon_lst):
        for (j, c2) in enumerate(codon_lst):
            if (i != j):
                try:
                    if (codon_table.forward_table[c1] == codon_table.forward_table[c2]):
                        rhoS += (pi[c1] * Q[(i, j)])
                    else:
                        rhoN += (pi[c1] * Q[(i, j)])
                except KeyError:
                    pass
    rhoS *= 3
    rhoN *= 3
    dN = (Nd / rhoN)
    dS = (Sd / rhoS)
    return (dN, dS)